Description
Recombinant full-length human CDK7 and Cyclin H1 were co-expressed by baculovirus in Sf9 insect cells using an N-terminal His tags. The gene accession number for CDK7 and Cyclin H1 are NM_001799 and NM_001239, respectively.
CDK7 gene is a member of the cyclin-dependent protein kinase family that is important regulators of cell cycle progression (1). CDK7 forms a trimeric complex with cyclin H and MAT1, which functions as a CDK-activating kinase (CAK). CDK7 is an essential component of the transcription factor TFIIH that is involved in transcription initiation and DNA repair. CDK7 is thought to serve as a direct link between the regulation of transcription and the cell cycle (2)